Bullying and Fun Thing Essay Example for Free

Bullying and Fun Thing Essay Schools from all over the world should really start preventing all this bullying thats going on. I find it bad that everyone makes fun of everyone. Either if it’s cyberbullying or just bullying, it’s a problem for a lot of students. In order to prevent bullying and all of this harassment, there’s so many things that I’d think can solve this problem. One of the first things that i think could be a solution for all of this would be talking to all of their parents, have a meeting about it, because most of their parents are also bullies. For example, that mother in Missouri who was making pretend she was a guy named Josh Evans on myspace and was cyberbullying her daughters friend just because she wanted revenge on that poor little girl and then she committed suicide. This all needs to stop! Parents are supposed to be setting an example for their children but they’re really not doing that correctly. More and more kids are losing their lifes because of this. It really isn’t a fun thing to do, the only thing you’re really doing is hurting and making them feel really bad. Noone would like it if someone else would do it to you. Changing the subject, the community should be more aware of this in my opinion. I feel like they need to step up a whole lot and make them have some changes around. The police should track on the computer everything that happens with everyone now a days, and if there’s any cyberbullying going on then they should just simply arrest them. They should be more stricter about it, not just around the community but also in schools. Sometimes I feel like theyre really not doing anything about bullying. I feel like noone cares at all, especially after what happened with the young adults that commited suicided these past few years.

Discuss and consider the role of women in Stephen Dedalus creative Ess

Discuss and consider the role of women in Stephen Dedalus' creative process, how is this reflected in the language and narrative of the novel? From the very first page of "A portrait of the artist as a young man", where Stephen Dedalus writes in simplistic and linear style and uses inarticulate expression and description in his story of the "moocow", to the last where he writes in journalistic form with a vast array of vocabulary and complex language, there is a progression, a maturing, a creative development; and this is influenced by the experiences, relationships and personal growth Stephen goes through as he grows up. Women are certainly an integral part of this creative process, from his experiences with Eileen, to sleeping with a prostitute, and his relationship with his mother, and his attempts to discover what his sensual feelings mean in this journey of self discovery, women feature prominently and have great significance in the creative process of Stephen's life. Stephen is a very interesting and intricate character, and comes freakishly close to the contemporary boy of the time, there is such a sense of realism which is conveyed through him by Joyce, most likely because he is based on himself. For example, Joyce had a mother devoted to Catholicism, as does Stephen, and Joyce was also educated at Clongowes. I think a key reason as to why women play such an important role in Stephen's creative development is the fact that on many occasions he does not know quite how to relate to them, he sees them as a completely different species and really doesn't know how to respond to them, as his experience with the prostitute will testify. Stephen's relationship with the opposite sex begins to deve... ...ourse to his destiny, and this significantly emphasises the importance of women in Stephen's development artistically, it is not even a girl with whom Stephen has any association, to him it is the gender as a whole, and therefore shows how women have played such a significant role for him. In conclusion, there is no doubt in my mind that across the novel, women play possibly the most important role of all in Stephen's artistic development, and it is because of them, whether it be the overbearing but supremely influential mother of Stephen, the experience with the prostitute, the love Stephen feels for Emma, or the epiphany on the beach with the wading young lady, that Stephen reaches the artist status which he eventually obtains and the intertwining suggests a fated nature which Joyce expertly conveys through his language and conscious style of writing. Discuss and consider the role of women in Stephen Dedalus' creative Ess Discuss and consider the role of women in Stephen Dedalus' creative process, how is this reflected in the language and narrative of the novel? From the very first page of "A portrait of the artist as a young man", where Stephen Dedalus writes in simplistic and linear style and uses inarticulate expression and description in his story of the "moocow", to the last where he writes in journalistic form with a vast array of vocabulary and complex language, there is a progression, a maturing, a creative development; and this is influenced by the experiences, relationships and personal growth Stephen goes through as he grows up. Women are certainly an integral part of this creative process, from his experiences with Eileen, to sleeping with a prostitute, and his relationship with his mother, and his attempts to discover what his sensual feelings mean in this journey of self discovery, women feature prominently and have great significance in the creative process of Stephen's life. Stephen is a very interesting and intricate character, and comes freakishly close to the contemporary boy of the time, there is such a sense of realism which is conveyed through him by Joyce, most likely because he is based on himself. For example, Joyce had a mother devoted to Catholicism, as does Stephen, and Joyce was also educated at Clongowes. I think a key reason as to why women play such an important role in Stephen's creative development is the fact that on many occasions he does not know quite how to relate to them, he sees them as a completely different species and really doesn't know how to respond to them, as his experience with the prostitute will testify. Stephen's relationship with the opposite sex begins to deve... ...ourse to his destiny, and this significantly emphasises the importance of women in Stephen's development artistically, it is not even a girl with whom Stephen has any association, to him it is the gender as a whole, and therefore shows how women have played such a significant role for him. In conclusion, there is no doubt in my mind that across the novel, women play possibly the most important role of all in Stephen's artistic development, and it is because of them, whether it be the overbearing but supremely influential mother of Stephen, the experience with the prostitute, the love Stephen feels for Emma, or the epiphany on the beach with the wading young lady, that Stephen reaches the artist status which he eventually obtains and the intertwining suggests a fated nature which Joyce expertly conveys through his language and conscious style of writing.

A Roman Catholic Understanding Of Justice In Health Care

Over the past hundreds of years, the Church has been involved in taking care of the health of the people.   The church has included religious men and women, and also laymen and laywomen, to ensure relevant healthcare is provided to the population.It has also utilized all the technological advancements to ensure the best medical care for the population.   It has ensured that the people serving in the healthcare sector should be disciplined, dedicated and have compassion towards the sick.The Catholic Church has provided healthcare and has given consideration to the poor and the not so well to do segments of the population.   It has also tried to improve the provision of healthcare, accessibility and upgrading the health status of the community to a higher level.In the US, the Catholic Church is one of the largest groups that provide healthcare for non-profit purposes.   It should also be noted that the Catholic Church provides healthcare to people belonging to various castes, r eligions and faiths[1].The Catholic Health Association of the US (CHAUS) was formed in the year 1915, and its basic aim was to unite all the Roman Catholic Healthcare organizations so that a common force could emerge in providing healthcare in the country[2].One of the main objectives of the Roman Catholic organizations in healthcare is to ensure that high quality services are provided right from birth until death.These services have to be provided to people belonging to various castes, faith, religions, races, ages, sex, etc.   This has ensured the people that no bias exists in providing healthcare.   Hence, people do consider the Catholic hospitals as universal and secular organizations in providing healthcare.   About 16 % of the population and about 20 % of all hospital admissions in the US is actually made into Catholic hospitals.   About 615 Catholic hospitals are existent in the US, out of a total of 5000.   70 % of these Catholic hospitals are located in urban area s, and 30 % in the rural areas.A wide range of services is provided by the Catholic hospitals, as they are interested in using the latest technological means in ensuring high quality services.   The Catholic hospitals have also given ample importance to family care, women’s health, emergency care, nursing, hospice, assisted living, residential facilities, newborn care, etc.The other sectors in which the Catholic Church has significant contributions include alcohol and drug treatment, psychiatric services, disaster management, dental care, geriatric services, HIV/AIDS services, nutrition, teenage care, etc.Another area in which the catholic hospitals have also given importance is the community health sector.   Community services in the year 2006 by all the Catholic hospitals in the US amounted to about $ 5.7 billion.These services were mainly to ensure that the public health needs were fulfilled and that the health status of the community could improve.   It is important to note that the Catholic hospitals have provided healthcare to the needy and the underprivileged segments of the population[3].[1] The Catholic Health Association of the United States (2007). Catholic Health Care in the United States, Retrieved on October 31, 2007, from the CHAUS Web site: http://www.chausa.org/NR/rdonlyres/68B7C0E5-F9AA-4106-B182-7DF0FC30A1CA/0/FACTSHEET.pdf[2] The Catholic Health Association of the United States (2007). Catholic Health Care in the United States, Retrieved on October 31, 2007, from the CHAUS Web site: http://www.chausa.org/NR/rdonlyres/68B7C0E5-F9AA-4106-B182-7DF0FC30A1CA/0/FACTSHEET.pdf[3] The Catholic Health Association of the United States (2007). Catholic Health Care in the United States, Retrieved on October 31, 2007, from the CHAUS Web site: http://www.chausa.org/NR/rdonlyres/68B7C0E5-F9AA-4106-B182-7DF0FC30A1CA/0/FACTSHEET.pdf   

Essay About Smart-Phones Industry Essay

Question 1 According to the task, I select the smart-phones industry as an example to figure out my own opinion. The marketing environment always consists of particular elements within a business’s external competitive environment and operating environment which is related to the demands of one product’s target consumer, that is also known as the target market member. The operating environment includes investors, employees, customers, creditors, and the marketing environment, and how to use a business and its obtained resources. The elements beyond the scope of the company’s control is a company’s remote environment composed of . Elements about the remote-environment incorporate current and expected economic, social, technical and political factors. The industry environment, which describes the situations of businesses supplying a similar kind of product or service, is also called the competitive environment. Analyzing the remote business environment is doing good at helping business people understand the innate character and tendency of the nowaday conditions. Remote analysis tells hidden issues and predicts directions. Competitive or industry analysis lends a hand for business managers knowing how can they make their outputs diverse and better than their competitors’. Operational analysis provides people an wide profile about the company. The operational profile benefits analysts in learning which business strategies are efficacious and after all which strategies may be needed to be optimized or abolished. The macro environment involves the external factors which can totally influence a business or industry. However, these factors are not often in the control or the management ability that a company equipped with. Factors typically also include economic, demographic and social, political, technological, and legal forces in business. Business managers as well as the owners often spend a lot of time and efforts to evaluate the worldwide economic environment to finally make a determination about the number and the effectiveness of all these factors. Economic factors are generally comprised of supply and demand, the actual number of competitors in this given market, availability of recently economic resources, and efficient manufacturing methods used by companies. All these factors influence this company’s output and latent profit margins while they are selling goods and services to their consumers. Free market economies obviously have more competition for the sake of that more individuals and businesses can benefit themselves through the raw materials, labor, and facilities in the market. Demographics and society refers to information which is about the buyers in this economic market. This information involves statistics on not only the consumer age, sex, race, religion, education, but also their household size, marital status, and also other similar information. Companies that use that information to create productions and marketing strategies in order to meet the demands of all the consumers in the designated macro environment. Whatever, this information interacts on general economic factors. Companies must have the ability to decide the consumer supply and need by assessing consumer benefits. Political forces generally indicate that the government agencies or apartments and policies must be responsible for this particular nation’s economy. Policies may involve business taxes, interest rate as well as the availability of currency. Otherwise, companies regular make a business decision that is based on the government involvement within a set business industry. Creating business distributions in these regions sometimes can reduce one company’s incomes and make it adapt to more regulations and laws, which also rises operating costs. Technological changes these recent decades have changed the method companies do trades in the very macro environment. Websites, network station, software based on Internet, and the fulfillment centers permit companies to put their goods and services in multiple and international economic markets. Strategies and performance reviews can favor owners as well as the managers to use the macro environment elements to product a few competitive advantages for their subsidiary companies. Recognition of strategic groups is the crucial side for industry itself analysis. A strategic group is comprised of firms in this industry which is following almost the same strategies that aimed at the same target market groups. Marketing environments are related to the stage which the product stand on in the whole business marketing life cycle. The life-cycle marketing environment, thus, the four marketing life-cycle stages incorporated introduction, growth, maturity or decline. New products emerge on stage Introductory which is often described by an invention or an original service. Environments in the growth stage are with high competition, that means there are many firms attempting to divide shares of the similar target market. When it comes to the maturity stage, sales are growing slowly since most buyers who buy this kind product are those people who have already bought the product before. Sales slow to a halt in the decline stage. However, there may be some types would not go through every stage in this marketing life cycle. Marketing environments could also be depictured obviously of no concern of the marketing life cycle. None market leaders exist in Fragmented marketing environments. And this kind environment consisted of plenty of relatively small firms. The global marketing environment is the station for worldwide selling products businesses. Smart phone companies are illustrations of businesses which connected close with this free global marketing environment. Question 2 Since I am one of Samsung’s loyal customers, let’s take Samsung LTD as an individual firm within the cellphone industry. Samsung is a famous company selling smart phones all around the world. When we go back to see the last ten years, the rapid development of the mobile technology is an very outstanding phenomenon which really forever changed nowadays society we live in. In spite of the challenges that the current mobile industry environment brings, mobile future buyers growth are continuing without stopping with the emergency of markets to lead the way. However, the mobile industry is facing with a good many key issues, the economic downturn as well as the saturation of the spectrum concerns included. Before going next, we must say something about marketing assets. It can fall into four categories as the following: Internal or marketing support assets is the first sort. For instance, cost advantages emerge when Samsung try many ways to save its cost; while, on the other hand, information systems together with market intelligence is also of consequence; moreover, Samsung do business bases on the feeling of their existing customer; technological skills is irreplaceable in today’s mobile industry. There are many other aspects in this professional realm. The next is called the Alliance-based assets which can be described by the following questions: do the company have a market access to entry the big market? How to access to this market? And what is their management skills? How to share technology and so on. Supply chain assets is another category. In this part, Samsung pays enough attention to distribution network and the relationships between workers and buyers; they deal wel l with the pockets of strength; they ensure the delivery lead times and security of supply which is hard to come by. The last one is Customer-based and reputation assets. Relationships between Samsung supplier and customers is good. Samsung has great company name as well as good reputation; nowadays Samsung really have the smart phone market’s domination and it can not get without superior products and the after-sale services. In order to develope Samsung’s marketing capabilities which refers to its ability to perform their fixed marketing-mix activities this firm must marshal all kinds of resources they have and then deliver the value to customer. Fortunately, Samsung did this, too. We can see advertising of Samsung’s product wherever we go, such as GALAXY S4. Resources portfolios are related to the project that organizations is described as collections of resources, assets, and capabilities. The crucial dimensions of resources portfolios are the significance of resources when it comes to create values for customers together with resource advantage relative to other smart phone producer, namely, competitors. What is the competitive advantage of Samsung? First, they save costs as possible compared to competitors based on the large-scale production or intensive production. Second, they have unique production and after service. Otherwise, Samsung has done good job in developing and exploiting all their resources. Since the emergency of Apple’s iPhone in phone market, most rival mobile manufacturers are spot in a hard ‘catch-up’ stage due to they fell behind after they did not find out how to use ‘touch screen’ technology through their cellphones’ production process. However, Samsung is a winner just like Apple. It exploited not only a unique system for Galaxy but also good screen-touch technology and applications. Around this rapidly developed world, the mobile industry is standing out. America is moving forward faraway but other countries keep banging away at their spectrum plans. The mobile industry, obviously, wants their governments to say something to clarified and regard their spectrum policies. Samsung start to research and develop spectrum since that more spectrum is needed whether they want many new opportunities to use mobile and wireless broadband technology to offer this society and the worldwide economy more help. With the number of mobile users are growing up day after day worldwide, the mobile industry is still put up with the declining Average Revenue Per User. The economic downturn, nevertheless, would not be the only element that driving down the ARPU; I believe that price wars involving in the increasingly competitive market and the trend for mobile users growth. Total cellphone sales and the mobile phone revenues were also decreasing in early years after the strong financial crisis. There is also evidence showing that the whole sales of smart phones are mounting while the handset sales totally being declining. Since Nokia has been losing its hegemony in market shares in the recent times. In spite of only this recent two or three years in the mobile market, Samsung has also become very very popular. Question 3 Sellers have three choices when they come in a market. Mass marketing is decided by a mass-produce mode and mass divide one product into pieces and try to attract each types of consumers. Target marketing is the decision to distinguish the different groups which make up a market to develop corresponding products and marketing mixes for each target market. Sellers in the last decade are continuing moving away from the mass marketing and they are moving towards their established target marketing since the latter is more helpful in cramping out market opportunities and developing successful product marketing mixes. Market segmentation is the procedure of dividing and measuring distinct groups of customers or potential buyers finally into subgroups in view of the same needs or preferences. Competitive positioning pay attention on how consumers consider about the sundry providing on the mobile market contrast with the other mobile producers. Not only the competitive positioning but the market segmentation must be formulated in this way so that the demand for consumers are fulled in ways which are better than competitors. Talking about so much, the definition of market positioning is not told. It is a sure process about formulating competitive positioning for each kind of product and the detailed mix of the product in marketing. The firm should be quite sure about their plan for how to introduce the function and advantage of the product to all these the consumers. How Samsung’s consumers think about it on significate attributes and decide the product’s position. That is to say, a company’s positioning relates to Samsung finding the appropriate ‘location’ among a group of buyers as well as their market segment is good so that they could d evelop a new product or provide better service in a customer desired way. While we define market segmentation as the process of placing the buyers in our target product-market and then divide them into multiple sub-groups for the members in every segmentation showing similar respond to a special positioning strategy. Market segmentation bases on the real information but not the marketers’ intuition. Obviously, Samsung catches the value of the procedure of market segmentation. They find out that customers are not all the same and other different products may probably take the fancy of buyers on multiform stages through their lifetimes. Considering about the mobile industry, for the sake of an illustration of this conception, Samsung practices what one preaches. The segmentation procedure refers to separating the big market into different groups of customers who might require separate products or marketing mixes, recognised that all buyers have unique needs and wants. It is generally possible in buyer markets to ensure comparatively homogeneous parts or segmentation of the whole mobile market rely on shared preferences, views, or actions that separate them from the others in the smart phone market. Diverse products and separate mixes may be needed in these segments, and one-to-one marketing approach segment is a decisive step in this contemporary. Generally speaking, B2B or B2C mode are used bu Samsung for a long time and its markets can be divided into parts using geographical and demographic descriptors, while diverse forms of behavioral descriptors and psychographics. Demographic descriptors include age like how old their customers are, gender which means female or male, household life cycle, income about their benefit, their occupation, their education degree, and race. Behavioral descriptors contain a plentiful collection of segment bases that benefits sought, behaviour about purchasing, usage about this kind of product, loyalty to distinct brand, their attitudes towards product and relationship seeking characteristics are included. Psychographic descriptors include personality and lifestyle, Samsung research every class for their buyers to gain more. References Hooley, G., Piercy, N., & Nicolaud, B. (2012). Marketing strategy and competitive positioning (5th ed.). New York: FT Prentice Hall. Oviatt, B. and McDougall, P. (1994), Toward a theory of international new ventures, Journal of International Business Studies, Vol. 25 No. 1, p. 45-64. Knight, G., Koed Madsen, T., Servais, P. 2004. An inquiry into born-global firms in Europe and the USA. International Marketing Review, 21/6, p645-665 Gleason, K., Madura, J., Wiggenhorn, J. 2006. Operating characteristics, risk and performance of born-global firms. International Journal of Managerial Finance. 2/2, p96-120 Lee, Li, Gongming, Qian, Zhengming, Qian. 2012. Early internationalization of small high tech ‘born-globals’. Strategic Marketing Review. 29/5. p536-561. Johanson, Jan and Jan-Erik VAHLNE. 1990. The Mechanism of Internationalization. International Marketing Review, vol. 7, no. 4, p. 11-24. Baird, Inga S. and ali. 1994. The Choice of International Strategies by Small Businesses. Journal of Small Business Management, vol. 32, no. 1, p. 48-59. Forrest, Janet E. 1990. Strategic Alliances and the Small Technology-Based Firm. Journal of Small Business Management, vol. 28, no. 3, p. 37-45. Larson, A. 1991. Partner Network : Leveraging External Ties to Improve Entrepreneurial Performance. Journal of Business Venturing, vol. 6, no. 3, p. 173-188. Doukas, J. and Lang, L. 2003. Foreign direct investment, diversification and firm performance, Journal of International Business Studies, Vol. 34, p. 153-72. Agmon, T. and Lessard, D.R. 1977. Investor recognition of corporate international diversification†, The Journal of Finance, Vol. 32 No. 4, p. 1049. Knight, G. and Cavusgil, S. 2004. Innovation, organizational capabilities, and the born-global firm, Journal of International Business Studies, Vol. 35, p. 124-41.

Resistance of bacterial to antimicrobial agents The WritePass Journal

Resistance of bacterial to antimicrobial agents Introduction Resistance of bacterial to antimicrobial agents IntroductionBeta- lactamase  Mutation at the target sitesEnzymatic modification Efflux of antibiotics from the cell by pumpAcquired Resistance by alternate metabolic pathwaysTreatment of superbugsConclusion  ReferenceRelated Introduction Bacterial resistance to antibiotics is a global problem in the treatment of bacterial infection. Bacterial resistance is a mechanism by which bacterial are able to overcome antibiotic meant to destroy or kill them, these bacterial multiply to cause disease in humans figure 1 (Patrick, 2003) Figure1 the non antimicrobial resistance and non antimicrobial resistance Although the most resistant bacterium can be inhibited or destroyed by using a high concentration of antibiotic, subjects on the other hand may not be able to bear the high concentration of antibacterial agents that may be required treat some bacterial infection or disease.   Bacterial species differ in their susceptibility to an antibiotic or antibiotics.   For instance some strains of Streptococcus pneumonia in Britain are inhibited by 0.01mg/l of benzyl penicillin thus the minimum inhibitory concentration, and that of Escherichia coli, a dose 32-64mg/l is needed to inhibit the growth or kill the bacterial but this becomes highly toxic to the human body cannot manage. This opens the view of clinical resistance, which is based on the on effect antibiotics on humans and misuse of antibiotics. Clinical resistance is therefore a process by which the type of infecting pathogenic bacterium, its point of attachment in the body, the distribution of antimicrobial in the body, its concen tration at site of infection and the immune status of the subject interact(Gerard,2011). Bacterium uses enzymes, efflux pump, gene, helix ring as well as plasmid to defend itself or to develop resistant to antibiotics. (figure2) Figure 2 structure of a resistant bacterium Beta- lactamase Beta-lactams are of copies penicillin, a large group of antibiotics that are made up of all the antibiotic agents with a four ring in their molecular structure. The bacterial cell wall serves as a protective tool for the bacterial against any foreign substances such as antibacterial agents, from entering inside the bacterial to destroy its internal protective structures. The beta-lactam antibiotic works by blocking the cell wall synthesis of the bacterial. Douglas (2002), but bacterial develop resistance to beta lactam by attacking the four ring structure shown in blue in figure of the beta-lactam through an enzymatic reactions (figure1). Bacterial produce beta lactamase enzyme to breaks the beta-lactam ring of the antibiotic and makes the antibiotic ineffective to block the bacterial cell wall synthesis and hence a resistance to the antibiotic (Miller et al., 2004). Figure3 structure of beta-lactam (www.users.rcn.com/jkimball.ma.ultranet/Biology/pages/A/Antibiotics)   Mutation at the target sites Some antibiotics such as Streptomycin inhibits bacterial protein synthesis by binding to the 16SrRNA and blocks the   function of the ribosome but   bacterial changes the 16SrRNA gene and limit the attraction of streptomycin to the 16S molecule bacterial mutate and acquire a new DNA. In imipenem resistant, Pseudomonosa aerugeninosa, lack the specific D2 porin and imipenem cannot break through the cell. Changing the main site of action may change the drug target in that antibiotic may enter the cell but may miss the target and may not be able to bind, the antibiotic may not be metabolised. This makes the antibiotic inactive in the bacteria and as result the bacterial develop tolerance (Springer et al., 2001). Enzymatic modification Ciprofloxacin act together with an enzyme gyrase to block its enzymatic action.   An alteration in each the gene that is gyraseA or gyraseB would change the molecular arrangement of the gyrase and as such limit the binding affinity of the enzyme for ciprofloxacin. It therefore prevents the antibiotic from blocking the gyrase and this process enables the bacteria cell more resistant to the antibiotic (ciprofloxacin) (Gerard, 2005) Efflux of antibiotics from the cell by pump Other bacterial such as the Escherichia coli create a multiple antibiotic resistance (MAR) outflow pump gives the bacterial with resistance to antibiotics such as tetracycline, erythromycin or nalidic acid.   The pump drives out the antibiotic from the cytoplasm of the bacterial cell and allows the bacterial to maintain the intracellular levels below the toxic or lethal concentration  Ã‚   The MAR pump is made of proteins MarA and MarB, whose production is blocked by the controlling protein Mar. Poole (2000) These changes get rid of the suppression control of Mar and leads to much production of the Mar A and B efflux pump. The bacterial cell wall is able to get rid of higher concentrations of antimicrobial agents and as such become resistant to the antibiotic (Cohen et al., 1988). Acquired Resistance by alternate metabolic pathways Resistance in bacteria may be acquired when a bacterium is been exposed to antibiotic for a long period of time for example vancomycin resistance in Escherichia coli. This may be by mutation or by gaining a new DNA. Plasmids are copying pieces portion of DNA, slighter than the bacteria genome which programme their transfer by copying into another bacterial strain. These bacteria may then carry and transfer resistance gene which as part of the DNA.Viruses that infects bacterial bacteriophages can pass on resistance, especially in staphylococcus, DNA is released when bacterial dead bacterial is taken up by a viable bacterial and this is possibly route for the spread of penicillin resistance in Streptococcus pneumonia. Bacterial possesses range of biochemical genetic systems for warranting the progression and diffusion of antibiotic resistance. Genes can appear by rapid transformation (Penrose, 1998). ‘Superbugs’ are used to describe a bacterium or microorganism that is able to resistant more than one or more commonly used antibiotics. Bacteria resistance to antibiotics are grouped according to the type of antimicrobial agent that they resist. The most common groups are: MRSA (Staphylococcus aureus strains resistant to mithescilin ) VRE (Entrococcus species resistant to vancomycin);   these type of bacteria live in the bowel   and usually cause infection such as pneumonia, heart or wound in subjects with weak immune system or subjects with chronic disease such as diabetes. PRSP (Streptococcus pneumoniae strains resistant to penicillin); ESBLs (Escherichia coli and other Gram-negative bacteria resistant to cephalosporin and Monobactams) (Gerard, 2011) Treatment of superbugs MRSA is a type of Staphylococcus aureus has develops a resistant to antibacterial activity of methicillin and the other penicillins Staphylococcus aureus may cause infection in the blood or on the skin disease such. Vancomycin is a glycopeptide that is effective for the treatment of MRSA. It is hard and large molecule that blocks the last step of bacterial cell wall synthesis through hydrogen bonds with D-alanyl-D-alamine end of the peptodoglycan (PDG) side chains(Reynolds,1989)). Subjects infected with   MRSA are treated with   vancomycin but very painful through the intramuscular route and a rapid administration into the veins may cause an allergic reaction called the red-man syndrome, therefore a   slow infusion   of 50mk/kg is given two times daily for 7 days.   Daptomycin is a broad spectrum antibiotic that has been approved by the American food and drug Administration for the treatment of MRSA, VRE and PSBP. It binds irreversibly to the bacteria cell membrane and depo larise it and more Potassium ions move out of the cell to create an inbalance of the ion-concentration gradient.   Currently, Daptomycin shows no cross-resistance. A dose of 4-6mg/kg is administered once daily for 7 days. It is not metabolised in the liver. Daptomycin interacts with the HMG-6A reductase inhibitors such as statin. Nausea, constipation and headache are the main side effects associated with the use of Daptomycin. Quinupristin was well used in the year 2000 for the treatment of hospital acquired infection. Quinupristin main function was to interfere with both the early and the last phase of bacterial protein synthesis but the major problem was that it has to required slow infusion for a large volume fluid just as vancomycin   and as such could only be used for inpatients   subjects(Despoina and Jordi,2006)). Dancer, an oral Streptogramin has been was developed and out 53 subjects 39 were successfully cured of MRSA infection. A new glycopeptide, MDL63246 with a sim ilar mechanism of action and pharmacokinetics as vancomycin is under early stages of development and would be more effective at lower dosages than vancomycin and less side effects. (Franz-Joseph and Mark, 1997) A new approach for VRE treatment is the blocking of oxazoliddines from flowing out of the bacterial cell and broad spectrum pumps of Gram negative bacterial is being studied for future treatment of VRE. (Livermore, 2003).Linezolid belongs to the oxazolinones class of antibiotics and it binds to the 50S ribosomal segment and blocks bacterial protein synthesis. can be administered intravenously or orally .Through the oral administration, a subject is given 600mg two times daily for 10-14 days and 600mg 30-120 minutes twice   daily for one week for intravenous route. Moxifloxacin is a drug of choice for the treatment of PRSP It work by inhibiting DNA synthesis by enhancing cleavage of DNA of the bacterial DNA enzyme complex of the DNA gyrase and type IV topoisomerase figure. The dose regime is based on the type of infection, for the treatment of acute bacterial sinusitis a 400mg of Moxifloxacin is given daily for 10 days and 400mg daily dose of Moxifloxacin for 7-14 days is used treat community acquired pneumonia by Streptococcus sp. Figure3 the mechanism of action of Fluoroquinolones (www.mecriticalcare,net/downloads/Dcourse/AntimicrobialAgents Tigecycline is currently used to treat ESBPLs treat Gram negative enteric rod such as E. coli and Gram negative bacilli such as the Pseudomonas spp. Tigecycline interfere with the bacterial protein synthesis by attaching to the 30S of the ribosomal subunit and this 100mg load dose is given initially and 50mg subsequent dose of every 12 hours is administered for seven days (figure3). (Wunderink et al., 2003) Figure3 Tigecycline binding to Ribosome 30S subunit   at:www.mecritcalcare.net/AntimicrobialAgent.    Conclusion Bacteria or microbes are constantly reproducing at a faster and becoming resistant to antimicrobial agents. Antimicrobial resistance is a global crisis new and more potent antibiotics would have to be developed to overcome the problem of antibiotic resistance. Identification of natural products and knowing their biosynthesis from the bacterial source would enable scientist to find well defined antibiotic structures to that could kill or destroy all kinds of bacterial. Scientist may target ribose DNA, RNA or the peptodoglycan.   Reference Brumfit, W.and Hamilton-Miller, J. (1989)   Methicilin-resistant Staphylococcus aureus. N Eng J Med 320:1188-1196 Cohen, S.P., McMurry, L.M. and Levy, S.B. (1988) marA locus causes decreased expression of OmpF porin in multiple-antibiotic-resistant (Mar) mutants of Escherichia coli. Journal of Bacteriology 170:5416-5422 Despoina, K.and Jordi, R. (2006) Hospital –acquired pneumonia in the 21st century: a review of existing treatment options and their impact on patient care. Expert Opin.Pharmacother 7 🙠 12) 1555-1569 Douglas, N.F. (2002)   Extended-Interval Dosing of Aminoglycoside Antibiotics in critically ill patients. Journal of Pharmacy Practice15:85-95 Franz-Joseph, S.and Mark, E.J. (1997) Antibiotics for treatment of infections caused by MRSA and elimination of MRSA carriage: What are the choices? International Journal of Antimicrobial Agents 9:1-19 Gerald, D.W. (2005)   Bacterial resistance to antibiotics: Enzymatic degradation and of   modification. Advance Drug Delivery Reviews 57:1451-1470 Gerald, D.W. (2011)   Molecular mechanism of antibiotic resistance. Chem.Commun. 47:4055-4061 Livermore, D.M. (2003) Linezolid in vitro mechanism and Antimicrobial spectrum. Journal of Antimicrobial chemotherapy 51:9-16 Miller,C.,Thomsen,C.G.,Mosseri,H.I. and Cohen,S.N.(2004)   SOS response induction by ÃŽ ²-lactams and bacterial defence against antibiotic lethality. Science 305:1629-1631 Patrick, F.M.D (2003) Antimicrobials: Modes of Action and mechanism of resistance. International Journal of Toxicology 22:135-143 Penrose, E. (1998)   Bacterial resistance to antibiotics-a case of unnatural selection. Creation research Society Quarterly 35:76-83 Peter, N.B. and Morris, J.B (2008) Clinical Pharmacology.edn 10.Churchil Livinstone.london Poole, K.(2000) Efflux-mediated resistance to Floroquinolones in-gram-negative bacteria. Antimicrobial Agents and Chemotherapy 44:2877-3884 Reynolds, P.E. (1989)   Structure, biochemistry and mechanism of action of glycopeptide antibiotics.EurJ.clin Micr infection.Dis 8:943-950 SpringerB.,Kidan,Y.P.,Prammananan,K.E.,Bottger,E.C. and Sander,P.(2001)   Mechanism of streptomycin resistance: selection of mutation in the 16S rRNA gene conferring resistance . Antimicrobial Agents and Chemotherapy 45:2877-2884 ww w.web-books.com/MoBio/free/ch8A.htm www.mecriticalcare,net/downloads/Dcourse/AntimicrobialAgents www.users.rcn.com/jkimball.ma.ultranet/Biology/Pages/A/Antibiotic

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